PRICE-BASED DEMAND-SIDE MANAGEMENT MODEL FOR INDUSTRIAL AND LARGE ELECTRICITY CONSUMERS

This article discusses a price-based demand-side management model for industrial and large power consumers. We have analyzed various factors affecting the improvement of energy efficiency on a national scale as well as at the level of select enterprises and large electricity consumers and have concluded that demand-side management is one the key areas of increasing energy efficiency, with the price-based consumption as its core element. Using the Russian electricity market as a model example, this article investigates the formation of all cost components of the ultimate power price – electricity, capacity and transmission services. Based on the results of the power cost component analysis, the article concludes that the price-based demand-side management can be applied to all price components and identifies areas and hours for optimal demand-side management in order to minimize the purchase price of electricity, while maintaining the aggregate demand. Based on the identified specifics, we have developed a price-based demand-side management model for industrial and large electricity consumers, taking into account the factors that limit the required management of the demand. The suggested model can be adapted for retail and wholesale electricity customers alike. Given that the Russian electricity market is largely similar to other power markets, such as Nord Pool, EPEX, Powernext, PJM, New England ISO, etc., the suggested management methods can be adapted for application in other countries. The article also discusses a communication strategy for the suggested model. The results of this research have high theoretical and practical importance and can be used in power purchase-related activities of industrial and other large consumers in any country where the electricity is priced according to market principles.


INTRODUCTION
The ongoing depletion of global hydrocarbon reserves used for the production of energy resources coupled with the continuously increasing electricity consumption in the developed and, especially, developing economies of the world lead to the ever increasing cost of energy in global and national energy markets. Figure 1 shows total energy consumption and electricity domestic consumption in the world in the period 1990-2017, and Figure 2 shows consumption price indices of different energy resources among the OECD countries in the period from 1997 to 2017. products, one of the global trends in a new high-tech world over the past 10-15 years has been a strong focus on energy saving and efficiency. The implementation of an energy saving policy allows, without heavy investments, to give momentum to social and economic development at the national level (Leslie et al., 2012).
Among the key effects of an energy efficiency policy at the level of the national economy, are: • Improving the competitiveness of products by reducing the price of purchased energy in their cost structure • Cost reduction along all budget areas • Improving the energy security of a national economy • For hydrocarbon exporting countries -increasing treasury incomes • Preservation of domestic hydrocarbon reserves • Introduction of innovations. Therefore, energy saving and efficiency are a pivotal area of a national policy and a core element of a national strategy for many developed and developing economies of the world (British Petroleum, 2017). Energy saving and efficiency have a special importance for the Russian economy due to several reasons that are summarized in Table 1.
Since 2009, after the adoption of the Federal Law "On Energy Saving and Improving Energy Efficiency and Amending Certain Legislative Acts of the Russian Federation," Russia has been implementing energy saving and energy efficiency mechanisms across all levels of the economy. However, as shown in Figure 3, the current energy intensity of the Russian GDP significantly lags behind the targets set by the national initiative called "Energy Saving and Improving Energy Efficiency by 2020." Electricity takes a special place among all energy resources which people use (International Energy Agency, 2017). It is the most common energy carrier in the world due to its wide-spread production, simplicity and low cost of transportation over long distances, distribution to a large number of consumers at the same time, applicability in any climate, and its ability to convert to other types of energy, such as mechanical, thermal and light energy. Moreover, most energy resources, including natural gas and coal, are exploited in order to produce electrical energy. Therefore, improvement of electricity efficiency leads to an increase in the efficiency of the using these commodities. Electricity efficiency is therefore the highest priority on the energy agenda of any country in the world.
The increased interest to the problem of energy efficiency has significantly augmented the investments in energy-saving R&D and production. New technological trends in the energy industry have triggered institutional and structural changes in the management and processing of energy resources, with the new functions of the grids (Volkova et al., 2011) and new economic and management fields appearing that contribute to the gradual reduction of system-wide costs at all levels of the production chain in the industry (Loginov and Loginov, 2012).
The formation of new economic fields manifests itself as a new type of relations between electricity generators and consumers, taking the form of a wholesale and a retail power markets. In the energy markets, electricity is purchased in real time, and market operators actually control the amount of generation and consumption between all market players at the same time, including estimation of the supply and demand according to consumption parameters.
New management fields are manifested in the form of new technologies being implemented for scheduling and management of the power processes from the national level to the level of the ultimate industrial and household customers (Chiu et al., 2013).
The essence of the changes in the power management boils down to increasing energy consumption data at all levels and improving its use and communication. This, in turn, leads to new energy players appearing on the arena, such as metering market operators, and stepping up the role of other players in the circulation of energy resources.
Smart grids are one of the most striking manifestations of the impact that innovations can bring to the power industry (Kobets and Volkova, 2010;Carmoab et al., 2014). Smart grids build on Inflated energy costs put a significant burden on the production costs of Russian manufacturers, which is especially noticeable in the times of economic downturn Environmental High emissions in the process of extraction and processing of energy resources the concept of a fully integrated, self-regulating and self-restoring electric power system that has a network topology and includes all generating sources, backbone networks (including interstate backbone power lines), local distribution networks and all types of power consumers controlled by a single communication network in real-time (IEEE Emerging Technology Portal, 2009). The smart grid concept has become a priority on the energy and innovations agenda of many global economies (Volkova and Salnikova, 2010). In the EU countries, smart grids develop under the Smart Grid European Technology Platform, and under the Energy Independence and Security Act in the USA (European Commission, 2006;. In Russia, the process of implementing the smart grid policy is in the conceptual phase yet. We believe that demand-side management (DSM) will come as one the most efficient methods for increasing energy efficiency as it has been successfully applied in many developed countries and demonstrates robust results.

DSM
Management of the demand is an accepted concept that is used by energy providers and customers worldwide and it is called "demand-side management," or DSM (Lampropoulos et al., 2013).
It may also be referred to as energy demand management (Government of United Kingdom, 2016) or demand-side response (DSR) (Torriti, 2015). The term DSM was introduced after the world oil crises that took place in 1973 and 1979 (Smith, 2006). These energy crises primarily affected the US economy and revealed a real threat to energy security at the national level (U.S. Department of State, 2012). "Demand-side management" was officially introduced by the US Electric Power Research Institute in the 1980s Balijepalli et al., 2011). In 1993, the International Energy Agency, which was formed by OECD member states after the "first oil shock" in 1974, laid the foundation for the global programs focusing on DSM technologies (International Energy Agency, 2018).
DSM is a pro-active form of economic interaction between electric power entities and end users, which provides mutually beneficial, cost-effective regulation of volumes and modes of energy consumption (Gitelman et al., 2013).
DSM aligns daily and annual demand schedules across regional and integrated power systems ( Figure 4 shows an example of an electricity demand schedule), which, in turn, helps reduce costs in production, transportation and distribution of electricity and, ultimately, lower the electricity tariffs for customers. DSM generates a significant economic impact by reducing the purchase price for all customers within a grid (Dziuba and Solovieva, 2018).
The demand of different consumers and the energy system in general may vary greatly over short and medium periods of time, depending on a number of factors, including weather, daylight hours, production schedules, etc. Figure 4 shows hourly electricity demand in different countries in 2018. As can be seen from the graph, annual demand in different countries differs both in terms of the general demand parameters and the demand curve during a year. Figure 5 shows a graph of hourly demand in various countries of the world during a week in December 2018. As can be seen from the figure, hourly demand in different countries demonstrates volatility trends which are specific for each country. Figure 2 also shows significant differences between the demand levels during business days and weekends in different countries.
The difference in the demand volatility of different territorial entities depends on their specifics, including: • Economic structure of a given territorial entity • Industry sectors that electricity consumers come from • Total electricity demand • Climate and geographic specifics of a given territorial entity • Other individual factors affecting the demand.
Demand curves of individual countries or territorial entities consist of total demand curves of all electricity consumers, including industry, household, transport, construction, etc. Figure 6 shows sample demand curves of different types of industrial customers.
As seen from the graphs, each customer has its own characteristic impact on the general demand in the local or integrated grids.
Generators adjust their schedules to the changing demand by generating more or less electricity. However, during peak hours, it is usually less efficient "peak" generators that supply the unmet demand, and the costs of using "peak" generators immediately affect the retail prices. Figure 6 demonstrates the pricing principle that is applied in Russian electricity spot market (the "day-ahead market") with a fluctuating demand. As can be seen from Figure 7, the purchase price of electricity changes proportionally to the fluctuations of demand parameters.
The uneven demand forces generators to build significant reserve capacity which is only used to meet short-term peak demand and is idle most of other time. The same is true about the grid infrastructure: Power lines are built to cover the demand volatility. Table 2 outlines the effects which consumers can get from the DSM. Therefore, by aligning the demand generators and distributors bring down their costs, which ultimately translates into lower tariffs for customers within a grid. DSM impacts the economy at all levels, as illustrated in Table 3.
Obviously, the implementation of DSM is critical for the Russian economy from the strategic point of view because the demand volatility problem exists at all levels in any country -from a single enterprise to the national grid system in general.
DSM activities strive to optimize the demand to its most even level so as to decrease the use of peak generators.
DSM smooths out the peaks and falls of electric loads in the grid, thereby reducing the costs of generators as well as the costs for maintaining excessive capacity and preventing incidents in the grid (Solovieva and Dziuba, 2017).
DSM technology is being widely deployed in more than 30 countries around the world including the USA (Shariatzadeha et al., 2015), Canada (López et al., 2019), UK (Chilvers et al., 2017), the European Union, Germany , France (Jacquot et al., 2017), Australia (Marwan et al., 2011), Denmark (Pavani et al., 2017), Japan (Shiraki et al., 2016), A study of the existing DSM programs around the world has revealed common approaches and tools that are used to manage energy demand, such as: Use of energy-saving equipment, transition to renewable electricity, differentiation of electricity tariffs, etc. The difference is only in the scale of such programs, which is associated with the volume of funding and government support for DSM initiatives.

DEMAND RESPONSE
DSM is enabled through stimulating electric utility consumers to synchronously change their demand schedule of electricity consumption. The change in power consumption of an electric utility to better match the demand for power with the supply is called demand response.
According to the reports of the Federal Energy Regulatory Commission of the United States, the demand response is defined as: "Changes in electric usage by end-use customers from their normal consumption patterns in response to changes in the price of electricity over time, or to incentive payments designed to induce lower electricity use at times of high wholesale market prices or when system reliability is jeopardized." Demand response can also be defined as "a wide range of actions which can be taken at the customer side of the electricity meter in response to particular conditions within the electricity system (such as peak period network congestion or high prices)." Demand side is the activity of electric utility consumers when they change their consumption pattern by throttling their production rate or postponing some tasks that require large amounts of electric power until peak periods of the power system. Some customers may switch part of their consumption to alternate sources, such as small distributed generation systems.
According to the reports of the Federal Energy Regulatory Commission of the United States, the demand response is defined as: "Changes in electric usage by end-use customers from their normal consumption patterns in response to changes in the price of electricity over time, or to incentive payments designed to induce lower electricity use at times of high wholesale market prices or when system reliability is jeopardized." Demand response can also be defined as "a wide range of actions which can be taken at the customer side of the electricity meter in response to particular conditions within the electricity system (such as peak period network congestion or high prices)" (Torriti, 2015).
Demand side is the activity of electric utility consumers when they change their consumption pattern by throttling their production rate or postponing some tasks that require large amounts of electric power until peak periods of the power system. Some customers may switch part of their consumption to alternate sources, such as small distributed generation systems.   Table 3: Economic effects of demand-side management at different levels of the economy Economic system level Effects Government Improving energy security by freeing up additional generating capacity Improving the energy efficiency of a national economy by reducing the energy costs of all end consumers Decreasing the budget spending by reducing customer subsidizing Increasing budget revenues due to the release of energy fuel and its potential export (mostly, natural gas) Improving the environmental safety of energy industry by reducing emissions Customers Decreasing energy tariffs due to the aligning of the daily demand schedules and reducing transmission losses Improving the quality of electricity, which positively impacts the stability of energy-receiving equipment and the quality of products Increasing the availability of connection to electric networks due to the release of grid capacity Power industry Lower investments in the generation mix due to reduced demand Reducing fuel costs in generation by reducing fuel reserves Lower operating costs in generation due to the decreased supply obligation and longer service life of the generating equipment Lower investments in the grids due to freeing up transmission capacity and longer service life of the transmission and switching equipment Lower operating costs in the grids due to the decrease in necessary maintenance Reducing incident rate and increasing the service life of the grid equipment Improving the reliability of equipment at the national grid level Increasing the service life of equipment at the national grid level Related industries Lower prices for primary energy resources (coal, gas, fuel oil) due to reduced demand from the energy sector Growth of innovations (software and technologies) aimed at managing electricity demand on the side of industrial customers Economic rationing system for electric power supply is a DSM system based on incentivizing consumers to manage their power consumption. Price incentives offer lower net unit pricing in exchange for reduced power consumption in peak periods. The direct implication is that users of electric power capacity not reducing usage during peak periods will pay "surge" unit prices.
Involuntary rationing is a DSM system accomplished via rolling blackouts during peak load periods with a view to prevent further demand surges.
Historically, DSR programs have focused on maximizing demand reduction which ultimately aimed at minimizing the cost of generating capacity. A modern DSR model aims at a more flexible change in the consumption pattern, taking into account the operation of variable renewable energy (VRE) units. VRE is the use of VRE units. VRE systems are based on generating electricity using the solar and wind energy. However, VRE sources are considered unstable as the natural conditions are prone to fluctuations.
Demand response may embrace a wide range of areas including energy efficiency, energy management at home and in buildings, distributed renewable resources and charging of electric vehicles.

PRICE-BASED DEMAND
Price-dependent demand is a model of flexible electricity consumption management in response to the price signals of the power market, aimed at minimizing electricity costs.
Price-based demand is a model for end-use customers to manage their electricity costs within the economic rationing system. The price-based demand is based on the economic incentives from the power system.
In most countries of the world, all electric power is sold and bought in the context of power markets which offer discrete pricing for the electricity. The electricity price generally reflects the demand and supply situation, enabling the customers to flexibly manage their power costs by adjusting their consumption patterns.
The price-based demand management on the side of industrial customers can actually bring down electricity costs without affecting the production rates. This economic effect is achieved due to the economically feasible redistribution of the production schedules and the associated electrical loads.

RESEARCH METHODOLOGY
The price of electric energy for industrial customers in Russia consists of three main components: electricity, capacity and transmission. Figure 8 illustrates the average structure of the electricity price for industrial customers in Russia.
The electricity and capacity prices are set through a competitive pricing mechanism, whereas the price of the power transmission services depends on adjustable price parameters.
While industrial customers can hardly impact the electricity market prices, they can certainly adjust their consumption patterns by adjusting production processes and putting on and off line their units which consume the most power.
From our point of view, the price-based demand management can actually impact all components of the power price, enabling customers to bring down their electricity costs.

The Electricity Component
The amount of obligation of an industrial consumer to pay for electricity, capacity and transmission is calculated individually according to the hourly electricity consumption in a given reporting month. The methodology for calculating the amount of obligations to pay for each price component has its own principles, rules and specifics.
The electricity payment obligation is calculated according to the hourly market prices on the day-ahead (spot) market and the corresponding amount of hourly electricity consumption. Figure 9 illustrates hourly prices on the spot power market. As can be seen from the figure below, the spot prices set for each hour have significant intraday volatility. The difference between the night hour prices and the daily peak prices may reach 2 times or more. Moreover, the spot prices differ between working days and weekends, which can also reach double value.
From our point of view, the price-based management of the hourly electrical loads should be accomplished through the redistribution of consumption from the periods with the highest price of electricity to the periods with economically reasonable prices, enabling industrial customers to save on their electricity costs by up to 50%.
The range of the price-based management should be defined according to the spot market forecasts.
Formula (1) is used to calculate the "electricity" component of the price, and formula (2) -the effect of the price-based management, which is calculated as the price difference before and after the demand management effort (2).
where, SWm is the price of electrical energy purchased by an industrial customer in the month m W t is the rate of electricity consumption by an industrial customer in hour t P spot t is spot market price in hour t ∑ m P BM is the purchase price of electricity in the balancing segment of the wholesale power market. ∑ m P BM is taken into account when the electricity is purchased on the wholesale market or in the event of the fifth or sixth price category in the retail market. We have also conducted extensive research regarding the management of energy costs in the sector ∑ m Ц БР .
where, ∆SW m is the saving on electricity purchase costs due to the pricebased demand management SW m is the cost of paying for electric energy before the application of price-based demand management SW m ' is the cost of paying for electric energy after the application of price-based demand management.

The Capacity Component
The amount of obligation to pay for electric energy is calculated each month based on the hourly schedule of power consumption of each participant. The amount of obligation to pay is calculated as the average capacity consumed by an industrial customer during the hours that are daily peak hours in a local grid, on the working days of a given month. Daily peak hours of a given local grid are limited to the scheduled peak hours. Figure 10 illustrates the calculation of the obligation to pay the capacity for an industrial customer.
As can be seen from Figure 3, the amount of obligation to purchase capacity does not depend on the daily peak demand of the given customer, but rather on the daily peak hour of the grid as such.
Daily peak hour of the grid is determined only for the working days of the corresponding month and always falls on one of the scheduled peak load hours (the blue zone on Figure 11).
Therefore, in order to reduce its obligation to purchase capacity, an industrial customer needs to shift its peak load hours to the hours that do not fall into the blue zone nor the grid's peak hours.
Prediction of the grid's peak hour with a fairly high probability can be accomplished using the historical data for the past few years.
The suggested approach allows industrial customers to reduce their capacity purchase costs by 10% to 80%. Formula (3)  where t=t_max_regio (4) where, W t is the rate of electricity consumption by an industrial customer in hour t t_max_region is the combined peak hour in a given region of Russia where the industrial customer purchases electricity in hour t on a working day of the month m n work d,m is the number of working days in the month m. t_max_region ϶ T_peak_SO T_peak_SO is intervals of the scheduled peak hours as approved by the System Operator of the Russian Grid.
where, ∆SP m is the saving on capacity costs due to the price-based demand management SP m is the cost of paying for capacity before the application of price-based demand management SP' m is the cost of paying for capacity after the application of price-based demand management.

The Transmission Component
The amount of obligation to pay for transmission services is calculated each month. DSM of the transmission costs can only be accomplished if the industrial customers could choose a twoprice tariff, which consists of the costs of maintaining transmission networks and the cost of technological losses.
The cost of technological losses does not depend on hourly load schedules, and their share in the total cost of transmission services does not exceed 20%.
The network maintenance costs are estimated for each participant according to hourly schedule of electricity consumption in a given month as the average hourly peak consumption of a given industrial customer during the scheduled peak hours on the working days ( Figure 12). Figure 5 shows an example of estimating the amount of obligation of an industrial customer to pay for network maintenance. As can be seen from the figure below, DSM is limited to the hours in the blue zone of the working days.
The price-dependent management of the hourly load schedule should consist in balancing the demand during periods of the scheduled peak hours. It should be noted that the peak hour schedule is available to consumers 1 year in advance.
The price-based DSM will allow industrial customers to smooth out their consumption peaks and reduce the amount of obligations to pay for the transmission services. The transmission-related costs can be calculated using formulas (6-9), and the effect of the price-based DSM -by using formula (10). is the cost of electricity transmission services at a twoprice tariff that takes into account the technological consumption (losses) in networks in the month m, (kW × h) (7).

ST
where, T m Maint is the tariff rate for the maintenance of electric networks in the month m VT2m is the value adopted for calculating obligations for payment for the network maintenance, in the month m (8).
where, ∆ST2 m is the saving on transmission costs due to the price-based DSM ST2 m is the cost of paying for transmission services before the application of price-based DSM ST m 2 ' is the cost of paying for transmission services after the application of price-based DSM.
It was found that all three components of the electricity price dependent the hourly daily consumption pattern and can therefore be managed on the side of the consumer (DSM) (11).  Figure 13 presents graphical examples of determining obligations to pay for various components of the electricity price based on a typical demand schedule. Graph A shows an example of estimating the cost of obligations to pay for capacity, Graph Bfor transmission and Graph C -the cost of purchasing electricity on the spot market.
As can be seen from the example of the cost of obligation to pay for the capacity in Graph A, when applying DSM during the daily peaks of the grid's combined peak demand (4), the obligation to purchase capacity decreases for the customer of the electricity VP m , and hence decreases the price of the capacity SP paid by the customer.
As seen from Graph B, DSM during the scheduled peak hours of the grid T_peak_SO (7) decreases the value adopted for calculation of obligation for payment for network maintenance VT2 m , and hence decreases the cost of transmission services paid by the consumer of electricity SП.
Also, as seen from Graph C, DSM during the periods of high spot prices P spot t (2) decreases the amount of electricity purchased at the maximum daily spot prices, and hence decreases the price of electricity purchased on the spot market SW by the consumer.
Therefore, DSM of all three components of the power price decreases the total cost of electricity SE purchased by consumers (9).
At the same time, a change in one price component, as a rule, entails a change in the other two components. This circumstance should be taken into account when optimizing the hourly schedule of electrical loads and making managerial decisions.

PRACTICAL APPLICATION
Based on the suggested approach to managing all three components of the power price, we have developed a price-based DSM model for industrial customers (Figure 14).
From our point of view, the calculation of the parameters used in the price-based DSM should be based not only on the demand and market indicators, but also take into account the technological and economic feasibility of adjusting the production processes which affect the hourly daily demand.
The application of the suggested price-based DSM model should be based on a large data array, which in turn puts forward stringent requirements for information support for the suggested approach. manufacturer located in the Samara Region, before and after the DSM actions. The demand was adjusted during the customer's own demand peaks and reallocated to the hours when the demand is minimal.
The initial value of power consumption at 11 and 12 h before the adjustment is 2.3 MW, after the adjustment -2 MW. The redistribution to the minimum hours is 0.1 MW for periods from 1 to 6 h. Assuming similar loads in all days of December 2018, we calculated the cost of purchased electricity before and after the DSM adjustment and the effect of DSM (Table 5).
As can be seen from the calculation results, due to the DSM measure this industrial customer not only optimized its general demand curve, but also decreased its electricity purchase costs in December 2018 by 311,278 rubles, or 8.3%. In the annual terms, the economic effect can reach several million rubles, which -in the context of an economic crisis, cash deficits and the cost-saving urge -is a serious outcome achievable without any large-scale investment costs.

CONCLUSIONS
Our research suggests several important conclusions. 1. The growing global energy consumption along with the upward trend of all kinds of energy resources on world energy markets suggest the price of energy resources will continue to increase in the future 2. The implementation of an energy saving policy allows, without heavy investments, to give momentum to social and economic development at the national level 3. A comparative analysis of the indicators and dynamics of the projected and actual energy intensity of Russia's GDP shows that the country is lagging in terms of energy efficiency, which necessitates the search and implementation of new solutions 4. Electricity demand in different countries of the world demonstrates high volatility which has different parameters and manifests both in absolute terms and in terms of the annual, weekly and intraday volatility 5. DSM is an effective tool for improving energy efficiency that is used by many economies globally. DSM allows to gain economic effect at all levels of the economy 6. The identified benefits of DSM at different levels of the grid system and levels of the economy highlight the scale and effectiveness of DSM efforts The period for each day 30 days in projection Actual production schedules Hourly discreteness. Real-time analysis

Scheduled production processes
Hourly discreteness. Value for the period from 1 day to 30 days in projection  High data discreteness should be one of the key information requirements. Table 4 presents the requirements which we suggest with respect to the volume and discreteness of the data to be used in the suggested model.
We will illustrate the possible effects of managing the demand at one of the industrial customers in the Samara region. Figure 15 shows an example of an hourly daily demand curve of a machine 7. Demand response is at the core of any DSM model, with the economic rationing of the demand as its most effective component 8. Price-based consumption is at the core of a demand response model, and it can be implemented in case of discrete price setting of the electricity 9. The existing mechanisms of the wholesale and retail electricity markets in Russia enable industrial customers to independently reduce their costs for the purchase of electricity through price-based demand management 10. The suggested integrated model of the price-based DSM allows consumers to adjust their production and demand according to the supply prices and thus minimize their energy purchase costs. 11. The application of the price-based DSM model allows to comprehensively manage all existing components of the electricity price, translating into a significant economic effect for an industrial customer 12. The implementation of the price-based DSM model should be based on a large amount of information while also take into account the specifics of production and processes. The scale of an economic effect from the implementation of the suggested model emphasizes its scientific and practical importance 13. Demand specifics of Russia's regions and the existing mechanisms of the wholesale and retail electricity markets create a platform for the development and implementation of new solutions in the field of DSM and the entailing increase the energy efficiency of the Russian economy 14. The results of our study have high theoretical and practical importance which manifests in their potential application in the DSM-related decisions that are taken at the level of countries and territorial entities with a view to reducing energy consumption and improving energy efficiency.

ACKNOWLEDGMENT
The work was supported by Act 211 Government of the Russian Federation, contract No. 02.A03.21.0011.